Cat. No. 3735
Chemical Name: 4,5-Dihydro-2-[4-(4-methyl-1H-imida
Biological ActivityPARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro; reduces myocardial infarct size in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sunderland et al (2011) 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J.Med.Chem. 54 2049. PMID: 21417348.
Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587. PMID: 18809672.
If you know of a relevant reference for BYK 49187 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses BYK 49187 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: BYK 49187, supplier, BYK49187, poly(adp-ribose), polymerases, inhibitors, inhibits, parp-1, parp-2, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent PARP inhibitor; orally bioavailableEntecavir
Potent and selective hepatitis B virus inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.