Cat. No. 3735
Chemical Name: 4,5-Dihydro-2-[4-(4-methyl-1H-imida
Biological ActivityPARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro; reduces myocardial infarct size in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Sunderland et al (2011) 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J.Med.Chem. 54 2049. PMID: 21417348.
Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587. PMID: 18809672.
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Keywords: BYK 49187, supplier, BYK49187, poly(adp-ribose), polymerases, inhibitors, inhibits, parp-1, parp-2, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products