BYK 204165

Cat. No. 3734

BYK 204165 C15H12N2O2 [1104546-89-5]

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Chemical Name: 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione

Biological Activity

Potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively).

Technical Data

M.Wt:
252.27
Formula:
C15H12N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
1104546-89-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587. PMID: 18809672.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BYK 204165 include:

Hamilton (2014) Cytotoxic effects of fascaplysin against small cell lung cancer cell lines. Lab Chip 12 1377. PMID: 24608973.

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Keywords: BYK 204165, supplier, BYK204165, PARP1, poly(ADP-ribose), polymerases, selective, inhibitors, inhibits, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products

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