Efonidipine hydrochloride monoethanolate
Cat. No. 3733
Chemical Name: 5-(5,5-Dimethyl-2-oxido-1,3,2-dioxa
Biological ActivitySelective blocker of L-type and T-type Ca2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Shin et al (2008) A selective T-type Ca2+ channel blocker R(-) efonidipine. Naunyn-Schmied.Arch.Pharmacol. 377 411.
Furukawa et al (2004) Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels. Br.J.Pharmacol. 143 1050. PMID: 15545287.
Masumiya et al (1998) Inhibition of myocardial L- and T-type Ca2+ currents by efonidipine: possible mechanism for its chronotropic effect. Eur.J.Pharmacol. 349 351. PMID: 9671117.
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Keywords: Efonidipine hydrochloride monoethanolate, supplier, L-type, T-type, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products