Cat. No. 3731
Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethy
Biological ActivityPotent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Byun et al (2009) Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells. Mol.Pharmacol. 76 734. PMID: 19574249.
King et al (2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem.Biol. 16 1045. PMID: 19875078.
Tiedemann et al (2009) Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo. Blood 113 4027. PMID: 19096011.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Pristimerin from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Pristimerin, supplier, MAGL, MGL, monoacylglycerol, lipase, inhibitors, lipases, NF-kB, NF-kappaB, NF-κB, inhibits, suppresses, activation, nuclear, factor, kappa, B, transcription, factors, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeableJZP 361
Potent and selective reversible MAGL inhibitorURB 602
Non-competitive MAGL inhibitor(S)-Crizotinib
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.