Boc-MLF

Cat. No. 3730

Boc-MLF Boc-Met-Leu-Phe

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Biological Activity

Antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.

Technical Data

M.Wt:
509.66
Formula:
C25H39N3O6S
Sequence:
Boc-MLF
Solubility:
Soluble to 2 mg/ml in DMSO
Storage:
Store at -20°C
CAS No:
67247-12-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Stenfeldt et al (2007) Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 30 224. PMID: 17687636.

Boxio et al (2005) The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 62 140. PMID: 16101820.

Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762.

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Keywords: Boc-MLF, supplier, formyl, peptide, receptor, 1, fMLF, FPR1, antagonists, Tocris Bioscience, Formyl Peptide Receptor Antagonist products

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