Cat. No. 3727
Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piper
Biological ActivityHighly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sheffler et al (2009) A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol.Pharmacol. 76 356. PMID: 19407080.
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Citations are publications that use Tocris products. Selected citations for VU 0255035 include:
Martin et al (2015) Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Mar Drugs 9 457. PMID: 26648844.
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Front Cell Neurosci 112 8124. PMID: 26080439.
Urrunaga et al (2015) M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury. Proc Natl Acad Sci U S A 78 66. PMID: 25452146.
Do you know of a great paper that uses VU 0255035 from Tocris? If so please let us know.
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Keywords: VU 0255035, supplier, selective, muscarinic, receptors, M1, antagonists, mAChR, acetylcholine, ACh, VU0255035, Tocris Bioscience, M1 Receptor Antagonist products