KU 0063794

Cat. No. 3725

KU 0063794 C25H31N5O4 [938440-64-3]

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Special Conditions

No more than 50mg may be supplied to any one individual in any one year period.

Chemical Name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

Biological Activity

Selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.

Licensing Information

Sold for research purposes only under agreement from KUDOS

Technical Data

Soluble to 10 mM in DMSO
>97 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Garcia-Martinez et al (2009) Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 421 29. PMID: 19402821.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for KU 0063794 include:

Hukelmann et al (2016) The cytotoxic T cell proteome and its shaping by the kinase mTOR. J Biol Chem 17 104. PMID: 26551880.

López-Cotarelo et al (2015) A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. Proc Natl Acad Sci U S A 290 827. PMID: 25425646.

Munson et al (2015) mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. Nat Immunol 34 2272. PMID: 26139536.

Wang et al (2014) SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One 8 e83941. PMID: 24391850.

Fei et al (2013) Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. PLoS One 8 e69104. PMID: 23874880.

Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. EMBO J 64 4361. PMID: 23963679.

Sengupta et al (2013) Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Free Radic Biol Med 110 18826. PMID: 24191005.

Do you know of a great paper that uses KU 0063794 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: KU 0063794, supplier, KU0063794, mammalian, target, of, rapamycin, inhibitors, inhibits, selective, mTOR, kinases, suppresses, cell, growth, Tocris Bioscience, mTOR Inhibitor products

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