Cat. No. 3718
Chemical Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)
Biological ActivitySelective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Suwa et al (2010) Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur.J.Pharmacol. 642 177. PMID: 20558154.
Suwa et al (2009) Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br.J.Pharmcol. 158 879.
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Citations are publications that use Tocris products. Selected citations for AS 1949490 include:
Hughes et al (2015) PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Front Neurosci 26 3867. PMID: 26337385.
Chang et al (2014) Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Mol Biol Cell 62 296. PMID: 24148856.
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Keywords: AS 1949490, supplier, AS1949490, SHIP2, inhibitor, inhibits, SH2, domain, containing, inositol, 5'phosphate, 2, diabetes, antidiabetic, inhibitors, Tocris Bioscience, Inositol Phosphatase Inhibitor products