AS 1949490

Cat. No. 3718

AS 1949490 C20H18ClNO2S [1203680-76-5]

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Chemical Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide

Biological Activity

Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects.

Technical Data

M.Wt:
371.88
Formula:
C20H18ClNO2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
1203680-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Suwa et al (2010) Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur.J.Pharmacol. 642 177. PMID: 20558154.

Suwa et al (2009) Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br.J.Pharmcol. 158 879.

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Citations are publications that use Tocris products. Selected citations for AS 1949490 include:

Hughes et al (2015) PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Front Neurosci 26 3867. PMID: 26337385.

Chang et al (2014) Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Mol Biol Cell 62 296. PMID: 24148856.

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Keywords: AS 1949490, supplier, AS1949490, SHIP2, inhibitor, inhibits, SH2, domain, containing, inositol, 5'phosphate, 2, diabetes, antidiabetic, inhibitors, Tocris Bioscience, Inositol Phosphatase Inhibitor products

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