Combretastatin A4

Cat. No. 1495

Combretastatin A4 C18H20O5 [117048-59-6]

Price and Availability

For Combretastatin A4 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: CRC 87-09, NSC 817373

Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
>99 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365. PMID: 17646428.

Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821. PMID: 11562761.

Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131. PMID: 8913833.

If you know of a relevant reference for Combretastatin A4 please let us know.

Citations are publications that use Tocris products. Selected citations for Combretastatin A4 include:

Arora et al (2009) Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity. J Biol Chem 69 1910. PMID: 19223556.

Do you know of a great paper that uses Combretastatin A4 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Combretastatin A4, supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC87-09, NSC817373, Tocris Bioscience, Antiangiogenic products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Angiogenesis in Cancer Life Science Poster

Taken from the Cancer Product Guide Edition 3

Angiogenesis in Cancer Life Science Poster

Our Angiogenesis in Cancer poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets. Request copy or view PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.