Cat. No. 1495
Alternative Names: CRC 87-09, NSC 817373
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho
Biological ActivityAntitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365. PMID: 17646428.
Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821. PMID: 11562761.
Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131. PMID: 8913833.
If you know of a relevant reference for Combretastatin A4 please let us know.
Citations are publications that use Tocris products. Selected citations for Combretastatin A4 include:
Arora et al (2009) Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity. J Biol Chem 69 1910. PMID: 19223556.
Do you know of a great paper that uses Combretastatin A4 from Tocris? If so please let us know.
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Keywords: Combretastatin A4, supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC87-09, NSC817373, Tocris Bioscience, Antiangiogenic products