Cat. No. 3715
Chemical Name: (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-
Biological ActivityExhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ingrassia et al (2009) Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents. J.Med.Chem. 52 1100. PMID: 19199649.
Lefranc et al (2009) Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol.Cancer Ther. 8 1739. PMID: 19531573.
Dumont et al (2007) The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 9 766. PMID: 17898872.
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Keywords: Narciclasine, supplier, Narciclasine, small, g, proteins, rhoA, rho, kinases, ROCK, signaling, signalling, modulators, anticancer, antiproliferative, agents, cell, cycle, inhibitors, inhibits, actin, Tocris Bioscience, Cell Cycle Inhibitor products
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