TCS PIM-1 4a

Cat. No. 3714

TCS PIM-1 4a C11H6F3NO2S [438190-29-5]

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Alternative Name: SMI-4a

Chemical Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

Biological Activity

Selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Xia et al (2009) Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J.Med.Chem. 52 74. PMID: 19072652.

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Keywords: TCS PIM-1 4a, supplier, TCSPIM14a, pim-1, pim-2, kinases, inhibitors, inhibits, selective, ATP-competitive, SMI-4a, Tocris Bioscience, Pim Kinase Inhibitor products

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