TCS PIM-1 4a
Cat. No. 3714
Alternative Name: SMI-4a
Chemical Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]
Biological ActivitySelective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Xia et al (2009) Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J.Med.Chem. 52 74. PMID: 19072652.
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Keywords: TCS PIM-1 4a, supplier, TCSPIM14a, pim-1, pim-2, kinases, inhibitors, inhibits, selective, ATP-competitive, SMI-4a, Tocris Bioscience, Pim Kinase Inhibitor products
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