PRIMA-1MET

Cat. No. 3710

PRIMA-1MET C10H17NO3 [5291-32-7]

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Alternative Name: APR-246

Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Biological Activity

Methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

Technical Data

M.Wt:
199.25
Formula:
C10H17NO3
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
5291-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Stuber et al (2009) PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 8 23. PMID: 19323829.

Shen et al (2008) PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27 6571. PMID: 18663359.

Bykov et al (2005) PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis. Oncogene 24 3484. PMID: 15735745.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PRIMA-1MET include:

Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641. PMID: 24265703.

Do you know of a great paper that uses PRIMA-1MET from Tocris? If so please let us know.

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Keywords: PRIMA-1MET, supplier, Restores, mutant, p53, activity, transcription, factors, APR-246, Tocris Bioscience, p53 products

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