MDL 72527

Cat. No. 3709

MDL 72527 C12H20N2.2HCl [93565-01-6]

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Chemical Name: N1,N4-Di-2,3-butadienyl-1,4-butanediamine dihydrochloride

Biological Activity

Polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo.

Technical Data

Soluble to 100 mM in water and to 75 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Basu et al (2009) A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 69 7689. PMID: 19773450.

Dogan et al (1999) Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J.Neurochem. 72 765. PMID: 9930751.

Bey et al (1985) N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J.Med.Chem. 28 1. PMID: 3965702.

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Keywords: MDL 72527, supplier, MDL72527, polyamine, oxidases, inhibitors, inhibits, POA, Tocris Bioscience, Other Oxygenase/Oxidase Inhibitor products

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