APcK 110

Cat. No. 3704

APcK 110 C20H16FN3O2 [1001083-74-4]

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Chemical Name: 6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine

Biological Activity

KIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50 = 175 nM). Caspase-dependant apoptosis inducer.

Technical Data

M.Wt:
349.36
Formula:
C20H16FN3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1001083-74-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Faderl et al (2009) Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer Res. 69 3910. PMID: 19383925.

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Keywords: APcK 110, supplier, APcK110, Kit, inhibitors, inhibits, Tocris Bioscience, Other RTKs Inhibitor products

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