Cat. No. 3704
Chemical Name: 6-(3,5-Dimethoxyphenyl)-3-(4-fluoro
Biological ActivityKIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50 = 175 nM). Caspase-dependant apoptosis inducer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Faderl et al (2009) Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer Res. 69 3910. PMID: 19383925.
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Keywords: APcK 110, supplier, APcK110, Kit, inhibitors, inhibits, Tocris Bioscience, Other RTKs Inhibitor products
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