Cat. No. 3703
Chemical Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-
Biological ActivitySelective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nakai et al (2009) K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 69 3901. PMID: 19351824.
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Keywords: K 858, supplier, mitotic, kinesin, Eg5, inhibitors, inhibits, cytoskeleton, motor, proteins, ATPase, K858, Tocris Bioscience, Kinesin Inhibitor products
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