Cat. No. 3703
Chemical Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-
Biological ActivitySelective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Nakai et al (2009) K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 69 3901. PMID: 19351824.
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Keywords: K 858, supplier, mitotic, kinesin, Eg5, inhibitors, inhibits, cytoskeleton, motor, proteins, ATPase, K858, Tocris Bioscience, Kinesin Inhibitor products