5,7-Dichlorokynurenic acid sodium salt

Cat. No. 3698

5,7-Dichlorokynurenic acid sodium salt C10H4Cl2NNaO3 [1184986-70-6]

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Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt

Biological Activity

Sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

Technical Data

Soluble to 100 mM in 1eq. NaOH
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554. PMID: 2172769.

Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I.

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Keywords: 5,7-Dichlorokynurenic acid sodium salt, supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products

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