CHPG Sodium salt

Cat. No. 3695

CHPG Sodium salt C8H7ClNNaO3 [1303993-73-8]

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Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt

Biological Activity

Sodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).

Technical Data

M.Wt:
223.59
Formula:
C8H7ClNNaO3
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1303993-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Bao et al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173. PMID: 11743947.

Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057. PMID: 10455248.

Doherty et al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265. PMID: 9144665.

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