Cat. No. 3691
Alternative Name: NN-DNJ
Chemical Name: (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-n
Biological ActivityGlucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697. PMID: 14757169.
Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867. PMID: 15128289.
Sawkar et al (2002) Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 99 15428.
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Keywords: N-Nonyldeoxynojirimycin, supplier, Glucosidase, inhibitors, inhibits, acid, α-glucosidase, alpha-glucosidase, GAA, α-1, 6-glucosidase, alpha-1, 6-glucosidaset, a-glucosidase, glycosylases, chemical, chaperone, NNDNJ, Tocris Bioscience, Glycosylase Inhibitor products
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