Cat. No. 3690

S26948 C28H25NO7S [353280-43-0]

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Chemical Name: [[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioic acid dimethyl ester

Biological Activity

Selective PPARγ agonist (EC50 = 8.83 nM). Drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice. Displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Sohn et al (2009) S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic insulin sensitivity in 48 h lipid infused rats. Eur.J.Pharmacol. 608 104. PMID: 19250932.

Carmona et al (2007) S 26948: a new specific peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects. Diabetes 56 2797. PMID: 17704298.

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Keywords: S26948, supplier, Peroxisome, Proliferator-activating, Receptors, PPARg, PPARγ, PPARgamma, agonists, antidiabetic, S26948, Tocris Bioscience, PPARγ Agonist products

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