Cevimeline hydrochloride

Cat. No. 3689

Cevimeline hydrochloride C10H17NOS.HCl [107220-28-0]

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Alternative Names: AF 102B, SNI 2011

Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride

Biological Activity

Selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

Technical Data

Soluble to 75 mM in water and to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hargreaves et al (1992) L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br.J.Pharmacol. 107 494. PMID: 1422595.

Fisher et al (1991) (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 257 392. PMID: 2019998.

Wanibuchi et al (1990) Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 187 479. PMID: 1963596.

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Keywords: Cevimeline hydrochloride, supplier, AF102B, SNI2011, selective, M1, muscarinic, cholinergic, receptors, acetylcholine, Ach, agonists, Tocris Bioscience, M1 Receptor Agonist products

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