SGS 518 oxalate
Cat. No. 3688
Alternative Name: LY 483518
Chemical Name: 1-Methyl-3-(1-methyl-4-piperindin-4
Biological ActivitySelective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197. PMID: 18044950.
Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133. PMID: 16865095.
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Keywords: SGS 518 oxalate, supplier, SGS518, 5-HTreceptors, serotonin, antagonists, schizophrenia, Alzheimers, LY483518, Tocris Bioscience, 5-HT6 Receptor Antagonist products
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