SGS 518 oxalate

Cat. No. 3688

SGS 518 oxalate C21H22F2N2O3S.C2H2O4 [445441-27-0]

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Alternative Name: LY 483518

Chemical Name: 1-Methyl-3-(1-methyl-4-piperindin-4-yl)-5-hydroxy-1H-indole 2,6-difluorobenzenesulfonic acid ester oxalate

Biological Activity

Selective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.

Technical Data

M.Wt:
510.51
Formula:
C21H22F2N2O3S.C2H2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
445441-27-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197. PMID: 18044950.

Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133. PMID: 16865095.

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Keywords: SGS 518 oxalate, supplier, SGS518, 5-HTreceptors, serotonin, antagonists, schizophrenia, Alzheimers, LY483518, Tocris Bioscience, 5-HT6 Receptor Antagonist products

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