Docosahexaenoic acid

Cat. No. 3687

Docosahexaenoic acid C22H32O2 [6217-54-5]

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Alternative Name: DHA

Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid

Biological Activity

Endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.

Technical Data

M.Wt:
328.49
Formula:
C22H32O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
6217-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Hossain et al (2009) Mechanism of docosahexaenoic acid-induced inhibition of in vitro1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells. J.Neurochem. 111 568. PMID: 19686246.

Zapata-Gonzalez et al (2008) Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids. J.Leukoc.Biol. 84 1172. PMID: 18632990.

Mata de Urqunia et al (2000) Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290 2140. PMID: 11118147.

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Keywords: Docosahexaenoic acid, supplier, RXR, agonists, retinoid, X, receptors, selective, Tocris Bioscience, Retinoid X Receptor Agonist products

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