Cat. No. 3687
Alternative Name: DHA
Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,1
Biological ActivityEndogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hossain et al (2009) Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells. J.Neurochem. 111 568. PMID: 19686246.
Zapata-Gonzalez et al (2008) Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids. J.Leukoc.Biol. 84 1172. PMID: 18632990.
Mata de Urqunia et al (2000) Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290 2140. PMID: 11118147.
If you know of a relevant reference for Docosahexaenoic acid please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Docosahexaenoic acid from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Docosahexaenoic acid, supplier, RXR, agonists, retinoid, X, receptors, selective, Tocris Bioscience, Retinoid X Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Synthetic progesterone analogC-DIM 12
Nurr1 activator; inhibits NF-κB-dependent gene expression(S)-Equol
Potent estrogen receptor β (ERβ) agonistAilanthone
Potent inhibitor of androgen receptor (AR)(±)-ML 209
RORγt inverse agonist; suppresses Th17 cell differentiationAGN 193109
High affinity pan-RAR antagonistSR 9243
Selective LXR inverse agonist
August 20 - 24, 2017
Paris , France