Bendamustine hydrochloride

Cat. No. 3681

Bendamustine hydrochloride C16H21Cl2N3O2.HCl [3543-75-7]

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Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride

Biological Activity

Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

Technical Data

Soluble to 25 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687. PMID: 19527193.

Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473. PMID: 18511926.

Schwanen et al (2002) In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096. PMID: 12357363.

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Keywords: Bendamustine hydrochloride, supplier, Cytostatic, agent, exhibits, DNA, alkylating, purine, analogue, properties, apoptosis, inducers, dna, synthesis, inhibitors, inhibits, chemotherapeutics, Tocris Bioscience, Apoptosis Inducing products

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