Cat. No. 3679
Chemical Name: 4-Chloro-N-[2-(2-thienyl)imidazo[1,
Biological ActivityPositive allosteric modulator of δ-subunit containing GABAA receptors (EC50 = 142 nM for α4β3δ receptors). Displays no effects on GABA responses mediated by α4β3γ2 and α1β3γ2 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wafford et al (2009) Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus. Neuropharmacology 56 182. PMID: 18762200.
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Citations are publications that use Tocris products. Selected citations for DS2 include:
Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci 36 607. PMID: 26758848.
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. Nat Methods 34 10219. PMID: 25080584.
Mirheydari et al (2014) Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site. Neurochem Res 39 1057. PMID: 24072672.
Do you know of a great paper that uses DS2 from Tocris? If so please let us know.
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Keywords: DS2, supplier, Positive, allosteric, modulators, delta, GABAA, receptors, Tocris Bioscience, GABAA Receptor Modulator products