NPY 5RA972

Cat. No. 3677

NPY 5RA972 C21H25N3O2 [439861-56-0]

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Chemical Name: N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide

Biological Activity

Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.

Technical Data

M.Wt:
351.44
Formula:
C21H25N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
439861-56-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Morris et al (2007) Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 25 1136. PMID: 17331209.

Block et al (2002) Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 45 3509. PMID: 12139462.

Turnbull et al (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51 2441. PMID: 12145156.

If you know of a relevant reference for NPY 5RA972 please let us know.

Citations are publications that use Tocris products. Selected citations for NPY 5RA972 include:

Zhang et al (2015) Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors. PLoS One 10 e0131124. PMID: 26131716.

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Keywords: NPY 5RA972, supplier, NPY5RA972, neuropeptide, Y, Y5, receptors, antagonists, potent, selective, NPYY5, neuropeptides, Tocris Bioscience, NPY Receptor Antagonist products

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