Cat. No. 3672
Biological ActivitySelective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). Displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Fang et al (2008) Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. Regul.Peptides 147 45.
Wang et al (2008) Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides 29 1183. PMID: 18406009.
Simonin et al (2006) RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc.Natl.Acad.Sci.USA 103 466.
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Citations are publications that use Tocris products. Selected citations for RF 9 include:
Alsaqati et al (2014) Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br J Pharmacol 171 701. PMID: 24138077.
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Keywords: RF 9, supplier, Selective, NPFF1, NPFF2, antagonists, npffr1, npffr2, Neuropeptide, FF, AF, Receptors, FF/AF, RF9, neuropeptides, Tocris Bioscience, Neuropeptide FF/AF Receptor Antagonist products
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