Cat. No. 3670
Chemical Name: Naphtho[1,2-d]thiazol-2-ylamine
Biological ActivityActivator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Brahler et al (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119 2323. PMID: 19380617.
Sankaranarayanan et al (2009) Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol.Pharmacol. 75 281. PMID: 18955585.
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Keywords: SKA 31, supplier, Activators, KCa3.1, KCa2.1, KCa2.2, Ca2+-activated, potassium, K+, channels, SK1, SK2, small, conductance, SKA31, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products
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