SR 3677 dihydrochloride

Cat. No. 3667

SR 3677 dihydrochloride C22H24N4O4.2HCl [1072959-67-1]

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Chemical Name: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride

Biological Activity

Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).

Technical Data

M.Wt:
481.37
Formula:
C22H24N4O4.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1072959-67-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Feng et al (2008) Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J.Med.Chem. 51 6642. PMID: 18834107.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SR 3677 dihydrochloride include:

El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Front Microbiol 307 C83. PMID: 24760984.

Do you know of a great paper that uses SR 3677 dihydrochloride from Tocris? If so please let us know.

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Keywords: SR 3677 dihydrochloride, supplier, potent, selective, Rho-kinase, ROCK, inhibitors, inhibits, Rho-associated, coiled-coil, kinases, stem, cells, SR3677, hydrochloride, Tocris Bioscience, Rho-Kinases Inhibitor products

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