SR 3677 dihydrochloride
Cat. No. 3667
Chemical Name: N-[2-[2-(Dimethylamino)ethoxy]-4-(1
Biological ActivityPotent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Feng et al (2008) Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J.Med.Chem. 51 6642. PMID: 18834107.
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Citations are publications that use Tocris products. Selected citations for SR 3677 dihydrochloride include:
El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Front Microbiol 307 C83. PMID: 24760984.
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Keywords: SR 3677 dihydrochloride, supplier, potent, selective, Rho-kinase, ROCK, inhibitors, inhibits, Rho-associated, coiled-coil, kinases, stem, cells, SR3677, hydrochloride, Tocris Bioscience, Rho-Kinases Inhibitor products
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