Tenofovir

Cat. No. 3666

Tenofovir C9H14N5O4P [147127-20-6]

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Alternative Names: PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine

Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid

Biological Activity

Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.

Technical Data

M.Wt:
287.21
Formula:
C9H14N5O4P
Solubility:
Soluble to 100 mM in 1.1eq. NaOH and to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
147127-20-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250. PMID: 9765248.

Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586. PMID: 8913470.

Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197. PMID: 7502044.

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Keywords: Tenofovir, supplier, Reverse, transcriptase, inhibitors, inhibits, Polymerases, RNA/DNA, Polymerase, antivirals, antiretrovirals, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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