Cat. No. 3666
Alternative Names: PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine
Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-m
Biological ActivitySelectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250. PMID: 9765248.
Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586. PMID: 8913470.
Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197. PMID: 7502044.
If you know of a relevant reference for Tenofovir please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Tenofovir from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Tenofovir, supplier, Reverse, transcriptase, inhibitors, inhibits, Polymerases, RNA/DNA, Polymerase, antivirals, antiretrovirals, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective hepatitis B virus inhibitorBRACO 19 trihydrochloride
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.