Cat. No. 3665
Chemical Name: 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl
Biological ActivityBrain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Munoz-Islas et al (2006) Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors. Br.J.Pharmacol. 149 82. PMID: 16880765.
Letienne et al (2005) Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J.Pharmacol.Exp.Ther. 315 849. PMID: 16027226.
Letienne et al (2003) Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J.Pharmacol.Exp.Ther. 305 749. PMID: 12606602.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Donitriptan hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Donitriptan hydrochloride, supplier, serotonin, 5-HT1B, 5-HT1D, 5-HT1B/1D, receptors, agonists, Tocris Bioscience, 5-HT1B Receptor Agonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.