Teijin compound 1

Cat. No. 3664

Teijin compound 1 C21H21ClF3N3O2.HCl [1313730-14-1]

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Chemical Name: N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride

Biological Activity

Potent chemokine CCR2b receptor antagonist (IC50 = 180 nM). Potently inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).

Technical Data

M.Wt:
476.32
Formula:
C21H21ClF3N3O2.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
1313730-14-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hall et al (2009) Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol.Pharmacol. 75 1325. PMID: 19297521.

Moree et al (2008) Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg.Med.Chem.Letts. 18 1869.

Moree et al (2004) Small molecule antagonists of the CCR2b receptor. Part 2: discovery process and initial structure-activity relationships of diamine derivatives. Bioorg.Med.Chem.Letts. 14 5413.

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Keywords: Teijin compound 1, supplier, Potent, CCR2b, antagonists, chemokines, receptors, Teijin, compound1, Tocris Bioscience, Chemokine CC Receptor Antagonist products

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