Cat. No. 3663
Alternative Name: SR 6452
Chemical Name: 1,1-Dimethylethyl-N-[(4-chloropheny
Biological ActivitySelective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 6 131. PMID: 21043485.
Meng et al (2008) Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 121 3629.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GSK 4112 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: GSK 4112, supplier, GSK4112, REV-ERBA, REV-ERBα, REV-ERBalpha, agonists, circadian, rhythms, SR6452, Tocris Bioscience, Rev-Erb Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Synthetic retinoid; induces differentiation of stem cellsSI-2 hydrochloride
Steroid receptor coactivator 3 (SRC-3) inhibitorSR 0987
T cell-specific RORγ (RORγt) agonistWAY 252623
Potent LXR agonistSR 9009
Rev-Erbα/β agonistSR 9238
Potent and selective LXR inverse agonist
December 3 - 7, 2016
San Francisco, CA,