Cat. No. 3661

BAN ORL 24 C27H35N3O2.2HCl [1401463-54-4]

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Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide

Biological Activity

Potent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50. PMID: 19445927.

Liao et al (2009) 1-Benzyl-N-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices. Eur.J.Pharmacol. 606 84. PMID: 19374842.

Goto et al (2006) Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity. J.Med.Chem. 49 847. PMID: 16451050.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BAN ORL 24 include:

Aatsinki et al (2014) Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions. Am J Physiol Cell Physiol 171 2351. PMID: 24428821.

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Keywords: BAN ORL 24, supplier, BANORL24, potent, selective, NOP, ORL1, OP4, nociceptin, orphanin, FQ, opioids, receptor-like, 1, receptors, antagonists, Tocris Bioscience, NOP Receptor Antagonist products

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