Cat. No. 3660
Alternative Name: BMS614
Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-
Biological ActivityNeutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Germain et al (2009) Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 16 479. PMID: 19477412.
Gehin et al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519. PMID: 10421757.
Schoenermark et al (1999) Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis. Ann.N.Y.Acad.Sci. 30 878.
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Citations are publications that use Tocris products. Selected citations for BMS 195614 include:
Flamini et al (2014) Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta. J Cell Mol Med 18 1113. PMID: 24720764.
Johansson et al (2013) Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun 4 2175. PMID: 23868472.
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Keywords: BMS 195614, supplier, BMS195614, retinoic, acid, receptor, RAR, alpha, α, RARa, antagonists, neutral, selective, BMS614, Tocris Bioscience, Retinoic Acid Receptor Antagonist products
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