BMS 195614

Cat. No. 3660

BMS 195614 C29H24N2O3 [253310-42-8]

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Alternative Name: BMS614

Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid

Biological Activity

Neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.

Technical Data

M.Wt:
448.51
Formula:
C29H24N2O3
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
253310-42-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Germain et al (2009) Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 16 479. PMID: 19477412.

Gehin et al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519. PMID: 10421757.

Schoenermark et al (1999) Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis. Ann.N.Y.Acad.Sci. 30 878.

If you know of a relevant reference for BMS 195614 please let us know.

Citations are publications that use Tocris products. Selected citations for BMS 195614 include:

Flamini et al (2014) Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta. J Cell Mol Med 18 1113. PMID: 24720764.

Johansson et al (2013) Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun 4 2175. PMID: 23868472.

Do you know of a great paper that uses BMS 195614 from Tocris? If so please let us know.

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Keywords: BMS 195614, supplier, BMS195614, retinoic, acid, receptor, RAR, alpha, α, RARa, antagonists, neutral, selective, BMS614, Tocris Bioscience, Retinoic Acid Receptor Antagonist products

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