GYY 4137 morpholine salt

Cat. No. 3658

GYY 4137 morpholine salt C11H16NO2PS2.C4H9NO [106740-09-4]

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Chemical Name: P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt

Biological Activity

Slow-releasing H2S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.

Technical Data

M.Wt:
376.47
Formula:
C11H16NO2PS2.C4H9NO
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
106740-09-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Liu et al (2013) Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice. Br.J.Pharmacol. [Epub ahead of print]. PMID: 23713790.

Lee et al (2011) The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 6 e21077. PMID: 21701688.

Whiteman et al (2010) The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages. Antioxid.Redox.Signal. 12 1147. PMID: 19769459.

Li et al (2008) Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). Circulation 117 2351. PMID: 18443240.

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Keywords: GYY 4137 morpholine salt, supplier, GYY4137, morpholine, h2s, hydrogen, sulfide, sulphide, donors, slow, releasing, release, vasodilator, antihypertensives, Tocris Bioscience, Miscellaneous Compound products

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