Cat. No. 3653

Allopregnanolone C21H34O2 [516-54-1]

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Alternative Name: 3a,5a-THPROG

Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one

Biological Activity

GABAA receptor positive allosteric modulator. Neuroactive steroid.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602.

Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565. PMID: 15959466.

Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759. PMID: 2160838.

If you know of a relevant reference for Allopregnanolone please let us know.

Citations are publications that use Tocris products. Selected citations for Allopregnanolone include:

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144. PMID: 24062647.

Do you know of a great paper that uses Allopregnanolone from Tocris? If so please let us know.

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Keywords: Allopregnanolone, supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, Tocris Bioscience, GABAA Receptor Modulator products

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