Cat. No. 3653
Alternative Name: 3a,5a-THPROG
Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Biological ActivityGABAA receptor positive allosteric modulator. Neuroactive steroid.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602.
Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565. PMID: 15959466.
Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759. PMID: 2160838.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Allopregnanolone include:
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144. PMID: 24062647.
Do you know of a great paper that uses Allopregnanolone from Tocris? If so please let us know.
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Keywords: Allopregnanolone, supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, Tocris Bioscience, GABAA Receptor Modulator products