Cat. No. 1350
Chemical Name: (4S)-4-[3-(Cyclopentyloxy)-4-methox
Biological ActivityLess active enantiomer of the PDE4 inhibitor rolipram (Cat. No. 0905). (R)-(-)-Rolipram (Cat. No. 1349) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147. PMID: 9681571.
Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53. PMID: 9337850.
Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105. PMID: 3019721.
If you know of a relevant reference for (S)-(+)-Rolipram please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-(+)-Rolipram include:
Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. J Biol Chem 171 2385. PMID: 24467222.
Brancaleone et al (2014) Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J Pharmacol Exp Ther 351 96. PMID: 25077524.
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123. PMID: 23143333.
Meyer et al (2012) Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization. Int J Nanomedicine 7 2449. PMID: 22654517.
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Keywords: (S)-(+)-Rolipram, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products
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