Neuromedin S (rat)

Cat. No. 3648

Neuromedin S (rat) Leu-Pro-Arg-Leu-Leu-His-Thr-Asp-Ser-Arg-Met-Ala-Thr-Ile-Asp-Phe-Pro-Lys-Lys-Asp-Pro-Thr-Thr-Ser-Leu-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2

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Biological Activity

Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide.

Technical Data

M.Wt:
4241.97
Formula:
C193H307N57O49S
Sequence:
LPRLLHTDSRMATIDFPKKDPTTSLGRPFFLFRPRN

(Modifications: Asn-36 = C-terminal amide)

Solubility:
Soluble to 0.50 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C
CAS No:
843782-19-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mitchell et al (2009) Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. Br.J.Pharmacol. 158 87. PMID: 19519756.

Ida et al (2005) Neuromedin S is a novel anorexigenic hormone. Endocrinology 146 4217. PMID: 15976061.

Mori et al (2005) Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 24 325. PMID: 15635449.

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Keywords: Neuromedin S (rat), supplier, Potent, endogenous, NMU1, and, NMU2, agonists, Neuromedin, U, Receptors, NeuromedinS, (rat), circadian, rhythms, Tocris Bioscience, Neuromedin U Agonist products

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