FR 171113

Cat. No. 3643

FR 171113 C19H11Cl3N2O4S [173904-50-2]

Price and Availability

For FR 171113 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester

Biological Activity

Protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.

Technical Data

M.Wt:
469.73
Formula:
C19H11Cl3N2O4S
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
173904-50-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kato et al (2003) Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur.J.Pharmacol. 473 163. PMID: 12892834.

Kato et al (1999) In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur.J.Pharmacol. 384 197. PMID: 10611442.

If you know of a relevant reference for FR 171113 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses FR 171113 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: FR 171113, supplier, FR171113, thrombin, protease-activated, receptor, 1, PAR1, antagonist, antagonists, antithrombotic, antiplatelet, Tocris Bioscience, Protease-Activated Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Cardiovascular Life Science Poster

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

New Products in this Area

ELARR>GG

Negative control for ELA-32 (Cat.No.6291).

ELA-32 (human)

Potent, high affinity apelin receptor agonist; stimulates angiogenesis

Parathyroid hormone (1-34) (bovine)

Parathyroid hormone (PTH) receptor agonist.

Parathyroid hormone (1-34) (rat)

Parathyroid hormone (PTH) receptor agonist

Peptide YY (3-36) human

NPY Y2 receptor agonist

ELA-14 negative control

Negative control for ELA-14 (Cat.No.6293).

ELA-14 (human)

Potent apelin (APJ) receptor agonist

Retrobradykinin

Reverse analog of Bradykinin

TASP 0390325

Potent and selective V1B receptor antagonist; orally bioavailable

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.