(R)-(-)-Rolipram

Cat. No. 1349

(R)-(-)-Rolipram C16H21NO3 [85416-75-7]

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Chemical Name: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Biological Activity

More active enantiomer of the PDE4 inhibitor rolipram (Cat. No. 0905); 2-10-fold more potent than the S-(+) enantiomer (Cat. No. 1350). Also available as part of the Phosphodiesterase Inhibitor Tocriset™.

Technical Data

M.Wt:
275.35
Formula:
C16H21NO3
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
85416-75-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147. PMID: 9681571.

Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53. PMID: 9337850.

Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105. PMID: 3019721.

If you know of a relevant reference for (R)-(-)-Rolipram please let us know.

Citations are publications that use Tocris products. Selected citations for (R)-(-)-Rolipram include:

Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Br J Pharmacol 171 2385. PMID: 24467222.

Do you know of a great paper that uses (R)-(-)-Rolipram from Tocris? If so please let us know.

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Keywords: (R)-(-)-Rolipram, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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