Cat. No. 3642
Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4
Biological ActivityPotent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297. PMID: 17850214.
Tian et al (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochem. 40 7084.
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Keywords: Src I1, supplier, Dual, site, Src, kinases, inhibitors, inhibits, Lck, family, SrcI1, Tocris Bioscience, Src Kinase Inhibitor products
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