SX 011

Cat. No. 3639

SX 011 C26H27ClFN3O3 [309913-42-6]

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Chemical Name: 6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide

Biological Activity

Potent p38α inhibitor (IC50 = 9 nM). Also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Displays no significant activity at p38γ, p38δ, ERK-2 and JNK-1.

Technical Data

M.Wt:
483.96
Formula:
C26H27ClFN3O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
309913-42-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lee and Dominguez (2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 12 2979. PMID: 16378500.

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Citations are publications that use Tocris products.

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Keywords: SX 011, supplier, SX011, p38, inhibitors, inhibits, MAPK, p38alpha, p38beta, p38a, p38b, signaling, signalling, Mitogen-Activated, Protein, Kinases, Tocris Bioscience, p38 MAPK Inhibitor products

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