Cat. No. 3639
Chemical Name: 6-Chloro-5-[[4-[(4-fluorophenyl)met
Biological ActivityPotent p38α inhibitor (IC50 = 9 nM). Also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Displays no significant activity at p38γ, p38δ, ERK-2 and JNK-1.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lee and Dominguez (2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 12 2979. PMID: 16378500.
If you know of a relevant reference for SX 011 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SX 011 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SX 011, supplier, SX011, p38, inhibitors, inhibits, MAPK, p38alpha, p38beta, p38a, p38b, signaling, signalling, Mitogen-Activated, Protein, Kinases, Tocris Bioscience, p38 MAPK Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective p38α/β inhibitor; orally bioavailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.