AF-DX 384

Cat. No. 1345

AF-DX 384 C27H38N6O2 [118290-26-9]

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Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Biological Activity

Potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).

Technical Data

M.Wt:
478.64
Formula:
C27H38N6O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
118290-26-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Grailhe et al (2009) Regional changes in the cholinergic system in mice lacking monoamine A. Brain Res.Bull. 78 283. PMID: 19111597.

Dopke et al (1995) AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. J.Pharmacol.Exp.Ther. 274 562. PMID: 7616446.

Miller et al (1991) Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J.Pharmacol.Exp.Ther. 259 601. PMID: 1941609.

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Keywords: AF-DX 384, supplier, Potent, M2/M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AFDX384, Tocris Bioscience, M2 Receptor Antagonist products

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