JWH 015

Cat. No. 1341

JWH 015 C23H21NO [155471-08-2]

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Chemical Name: (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

Biological Activity

Selective CB2 agonist (Ki values are 13.8 and 383 nM as measured at human cloned CB2 and CB1 receptors expressed in CHO cells).

Technical Data

M.Wt:
327.43
Formula:
C23H21NO
Solubility:
Soluble to 10 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
155471-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837. PMID: 10525107.

Pertwee et al (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635. PMID: 10469884.

Griffin et al (1997) Evidence for the presence of CB2-like receptor on peripheral nerve terminals. Eur.J.Pharmacol. 339 53. PMID: 9450616.

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Citations are publications that use Tocris products. Selected citations for JWH 015 include:

Agudelo et al (2016) Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol 6 1452. PMID: 26733986.

Verty et al (2015) Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice. PLoS One 10 e0140592. PMID: 26588700.

DiPatrizio et al (2011) Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A 108 12904. PMID: 21730161.

Preet et al (2011) Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer Prev Res (Phila) 4 65. PMID: 21097714.

Ehrhart et al (2005) Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2 29. PMID: 16343349.

Jiang et al Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS One 2 e641. PMID: 17653268.

Do you know of a great paper that uses JWH 015 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: JWH 015, supplier, Selective, CB2, agonists, Cannabinoids, Receptors, JWH015, cb2r, Tocris Bioscience, CB2 Receptor Agonist products

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