Cat. No. 3635
Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-
Biological ActivityNon-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses BPIPP from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: BPIPP, supplier, Non-competitive, GC, inhibitors, inhibits, Guanylyl, Cyclases, Tocris Bioscience, Guanylyl Cyclase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent soluble guanylyl cyclase (sGC) activatorBAY 41-8543
Guanylyl cyclase (sGC) stimulator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.