Cat. No. 3635
Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-
Biological ActivityNon-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440.
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Keywords: BPIPP, supplier, Non-competitive, GC, inhibitors, inhibits, Guanylyl, Cyclases, Tocris Bioscience, Guanylyl Cyclase Inhibitor products