Ryanodine

Cat. No. 1329

Ryanodine C25H35NO9 [15662-33-6]

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Chemical Name: 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

Biological Activity

Potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

Technical Data

M.Wt:
493.55
Formula:
C25H35NO9
Solubility:
Soluble to 10 mM in ethanol and to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
15662-33-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Bianchi (1997) Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. Biochem.Pharmacol. 53 909. PMID: 9174102.

Sutko et al (1997) The pharmacology of ryanodine and related compounds. Pharmacol.Rev. 49 53. PMID: 9085309.

Sutko et al (1985) Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed.Proc. 44 2984. PMID: 2415406.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ryanodine include:

Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. J Neurosci Res 10 e0125974. PMID: 25933382.

Zhang et al (2015) Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel. Pflugers Arch 8 10239. PMID: 26617732.

Nordman and Kabbani (2014) Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. J Neurosci 28 2995. PMID: 24687992.

Kyle et al (2013) Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists. Korean J Physiol Pharmacol 305 C609. PMID: 23804200.

Lotteau et al (2013) Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle. PLoS One 8 e58673. PMID: 23536811.

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Am J Physiol Cell Physiol 8 e66404. PMID: 23799098.

Begum et al (2012) DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. J Neurochem 120 622. PMID: 22129278.

Few et al (2012) Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 109 E452. PMID: 22308469.

Low et al (2012) Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner. PLoS One 7 e46999. PMID: 23056554.

Zhou et al (2012) Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J Appl Physiol (1985) 112 627. PMID: 22114176.

Fernández-Velasco et al (2011) RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS One 6 e20863. PMID: 21673970.

Kim et al (2011) Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells. PLoS One 15 431. PMID: 22359482.

Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545. PMID: 21844187.

Xu et al (2011) The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. PLoS One 31 17074. PMID: 22114277.

Karwatsky et al (2010) Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling. J Lipid Res 51 1144. PMID: 19965585.

Kim et al (2010) Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. Int J Clin Exp Pathol 19 783. PMID: 20001453.

Gerich et al (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. FASEB J 458 937. PMID: 19430810.

Dror et al (2008) Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. J Biol Chem 283 9909. PMID: 18174159.

Larina and Thorn (2005) Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses. J Cell Sci 118 4131. PMID: 16118245.

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Keywords: Ryanodine, supplier, Ca2+, release, inhibitors, inhibits, Calcium, Signaling, Signalling, Agents, General, Tocris Bioscience, Ryanodine Receptor Inhibitor products

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