Ryanodine

Cat. No. 1329

Ryanodine C25H35NO9 [15662-33-6]

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Chemical Name: 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

Biological Activity

Potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

Technical Data

M.Wt:
493.55
Formula:
C25H35NO9
Solubility:
Soluble to 10 mM in ethanol and to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
15662-33-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bianchi (1997) Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. Biochem.Pharmacol. 53 909. PMID: 9174102.

Sutko et al (1997) The pharmacology of ryanodine and related compounds. Pharmacol.Rev. 49 53. PMID: 9085309.

Sutko et al (1985) Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed.Proc. 44 2984. PMID: 2415406.

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Citations are publications that use Tocris products. Selected citations for Ryanodine include:

Begum et al (2012) DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. J Neurochem 120 622. PMID: 22129278.

Few et al (2012) Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 109 E452. PMID: 22308469.

Low et al (2012) Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner. PLoS One 7 e46999. PMID: 23056554.

Zhou et al (2012) Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J Appl Physiol (1985) 112 627. PMID: 22114176.

Fernández-Velasco et al (2011) RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS One 6 e20863. PMID: 21673970.

Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545. PMID: 21844187.

Karwatsky et al (2010) Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling. J Lipid Res 51 1144. PMID: 19965585.

Dror et al (2008) Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. J Biol Chem 283 9909. PMID: 18174159.

Larina and Thorn (2005) Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses. J Cell Sci 118 4131. PMID: 16118245.

Do you know of a great paper that uses Ryanodine from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Ryanodine, supplier, Ca2+, release, inhibitors, inhibits, Calcium, Signaling, Signalling, Agents, General, Tocris Bioscience, Ryanodine Receptor Inhibitor products

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