Flumazenil

Cat. No. 1328

Flumazenil C15H14FN3O3 [78755-81-4]

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Alternative Name: Ro 15-1788

Chemical Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

Biological Activity

Benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. Centrally active upon systemic administration in vivo.

Technical Data

M.Wt:
303.29
Formula:
C15H14FN3O3
Solubility:
Soluble to 25 mM in DMSO and to 5 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
78755-81-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Atack et al (1999) Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABAA receptors. Neuropsychopharmacology 20 255. PMID: 10063485.

Dobl (1999) New insights into the mechanism of action of hypnotics. J.Psychopharmacol. 13 S11. PMID: 10667451.

Polc et al (1981) Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788. Naunyn Schmiedebergs Arch.Pharmacol. 316 317. PMID: 7196507.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Flumazenil include:

Joensuu et al (2014) Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation. PLoS One 9 e89321. PMID: 24586687.

Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther 347 235. PMID: 23902941.

Leppä et al (2011) Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations. PLoS One 6 e24159. PMID: 21912668.

Linden et al (2011) Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors. Front Neurosci 5 3. PMID: 21270945.

Do you know of a great paper that uses Flumazenil from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Flumazenil, supplier, Benzodiazepine, antagonists, GABAA, Receptors, Ro151788, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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