Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Cat. No. 3633

Adenosine 5'-(a,b-methylene)diphosphate sodium salt C11H16N5NaO9P2 [89016-30-8]

Price and Availability

For Adenosine 5'-(α,β-methylene)diphosphate sodium salt pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: AMPCP, APCP

Chemical Name: α,β-Methyleneadenosine 5'-diphosphate monosodium salt

Biological Activity

Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.

Technical Data

Soluble in water (supplied pre-dissolved at a concentration of 10mM)
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kur et al (2014) Purinergic control of vascular tone in the retina. J.Physiol. 592 491. PMID: 24277867.

Niemelä et al (2008) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 38 2718. PMID: 18825744.

Ujházy et al (1996) Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer. 68 493. PMID: 8945621.

If you know of a relevant reference for Adenosine 5'-(α,β-methylene)diphosphate sodium salt please let us know.

Citations are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:

Caiazzo et al (2016) Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem.Pharmacol. 112 72. PMID: 27188793.

Do you know of a great paper that uses Adenosine 5'-(α,β-methylene)diphosphate sodium salt from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Adenosine 5'-(a,b-methylene)diphosphate sodium salt, supplier, [3768-14-7], MS, multiple, sclerosis, Ecto-5'-nucleotidase/, CD73, inhibitors, inhibits, adenosine, doxorubicin-resistance, vasoconstrictor, NT5E, eN, eNT, 5', nucleotidase, ecto-5'-NT, 5-(a,b-methylene)diphosphate, Tocris Bioscience, Other ATPase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

NMS 873

Potent and selective valosine containing protein (VCP; p97) allosteric inhibitor

Sign-up for new product e-alerts
divider line

ISSCR 2017

Win a $1,000 travel grant

ISSCR Travel Grant 2017

Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.