Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Cat. No. 3633

Adenosine 5'-(a,b-methylene)diphosphate sodium salt C11H16N5NaO9P2 [89016-30-8]

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Alternative Names: AMPCP, APCP

Chemical Name: α,β-Methyleneadenosine 5'-diphosphate monosodium salt

Biological Activity

Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.

Technical Data

Soluble in water (supplied pre-dissolved at a concentration of 10mM)
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kur et al (2014) Purinergic control of vascular tone in the retina. J.Physiol. 592 491. PMID: 24277867.

Niemelä et al (2008) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 38 2718. PMID: 18825744.

Ujházy et al (1996) Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer. 68 493. PMID: 8945621.

If you know of a relevant reference for Adenosine 5'-(α,β-methylene)diphosphate sodium salt please let us know.

Citations are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:

Caiazzo et al (2016) Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem.Pharmacol. 112 72. PMID: 27188793.

Do you know of a great paper that uses Adenosine 5'-(α,β-methylene)diphosphate sodium salt from Tocris? If so please let us know.

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Keywords: Adenosine 5'-(a,b-methylene)diphosphate sodium salt, supplier, [3768-14-7], MS, multiple, sclerosis, Ecto-5'-nucleotidase/, CD73, inhibitors, inhibits, adenosine, doxorubicin-resistance, vasoconstrictor, NT5E, eN, eNT, 5', nucleotidase, ecto-5'-NT, 5-(a,b-methylene)diphosphate, Tocris Bioscience, Other ATPase Inhibitor products

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