Forskolin

Cat. No. 1099

Forskolin C22H34O7 [66575-29-9]

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Chemical Name: [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

Biological Activity

Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742, 4423 and 4703). Also available as part of the PKA Tocriset™.

Technical Data

M.Wt:
410.51
Formula:
C22H34O7
Solubility:
Soluble to 10 mM in ethanol and to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
66575-29-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. 341 651. PMID: 23868920.

Kim et al (2005) cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK. Neuroreport 16 1357. PMID: 16056139.

Laurenza et al (1989) Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? TiPS 10 442. PMID: 2692256.

Awad et al (1983) Interactions of forskolin and adenylate cyclase. J.Biol.Chem. 258 2960. PMID: 6681815.

Seamon et al (1983) Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J.Med.Chem. 26 436. PMID: 6681845.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Forskolin include:

Avanzato et al (2016) Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling Scientific Reports 6 32602. PMID: 27586846.

Chan et al (2016) ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Cell 6 26119. PMID: 27189808.

Ang et al (2015) The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes. Ann Clin Transl Neurol 5 8134. PMID: 25633224.

Baron et al (2015) The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Sci Rep 6 e1629. PMID: 25654762.

Belgacem and Borodinsky (2015) Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Eur J Neurosci 112 4140. PMID: 25829542.

Ben-Simon et al (2015) A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. Pflugers Arch 12 396. PMID: 26166572.

Broadbent et al (2015) The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor. Sci Rep 467 1783. PMID: 25277268.

Brust et al (2015) New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Cell Rep 93 85. PMID: 25449598.

Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by dopamine. Elife 4. PMID: 26516682.

Cooke et al (2015) Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor. Cell Death Dis 172 593. PMID: 24697554.

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130. PMID: 25406263.

Emery et al (2015) Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform. J Cell Mol Med 87 928. PMID: 25769305.

Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Stem Cell Reports 19 210. PMID: 25266063.

Li et al (2015) Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice. Mol Pharmacol 4 246. PMID: 25737957.

Muñoz-Llancao et al (2015) Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. Biochim Biophys Acta 35 11315. PMID: 26269639.

Parnell et al (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Mol Metab 1853 1749. PMID: 25913012.

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Neurosci 2. PMID: 26465004.

Presley et al (2015) Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist. Biochem Pharmacol 3 e00159. PMID: 26196013.

Siuda et al (2015) Optodynamic simulation of β-adrenergic receptor signalling. Eneuro 6 8480. PMID: 26412387.

Walker et al (2015) A second trigeminal CGRP receptor: function and expression of the AMY1 receptor. Nat Commun 2 595. PMID: 26125036.

Zhu et al (2015) Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. Pharmacol Res Perspect 35 621. PMID: 25589756.

Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369. PMID: 25065880.

Chou et al (2014) Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. PLoS One 9 e99432. PMID: 24918932.

Felizola et al (2014) PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. Glia 52 159. PMID: 24403568.

Muthusamy et al (2014) A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence. Stem Cell Reports 3 169. PMID: 25068130.

Shelton et al (2014) Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells. Br J Pharmacol 3 516. PMID: 25241748.

Vandame et al (2014) The spatio-temporal dynamics of PKA activity profile during mitosis and its correlation to chromosome segregation. Cell Cycle 13 3232. PMID: 25485503.

Waheed et al (2014) Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner. Br J Pharmacol 171 2659. PMID: 24116661.

Yang et al (2014) PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling. J Biol Chem 66 83. PMID: 24225179.

Ehrlich et al (2013) Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. Mol Pharmacol 84 476. PMID: 23842570.

Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627. PMID: 24121738.

Pale et al (2013) Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties. Neuroscience 245 74. PMID: 23603516.

Sohn et al (2013) Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. J Mol Endocrinol 152 612. PMID: 23374353.

Tao et al (2013) cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. Br J Pharmacol 8 e71441. PMID: 23951163.

Wiseman et al (2013) Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase. J Biol Chem 288 17803. PMID: 23640883.

Bolognini et al (2012) AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor. Br J Pharmacol 165 2561. PMID: 21615724.

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. J Neurosci 35 507. PMID: 22304466.

Horváth et al (2012) A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury. J Neurosci 165 2462. PMID: 21449982.

Kaufman et al (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. J Neurosci 32 3992. PMID: 22442066.

Korboukh et al (2012) Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. J Med Chem 55 6467. PMID: 22738238.

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123. PMID: 23143333.

Mitra et al (2012) Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity. Nat Neurosci 15 250. PMID: 22179109.

Tran et al (2012) Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors. Assay Drug Dev Technol 10 37. PMID: 22066912.

Bonetti and Surace (2010) Mouse embryonic retina delivers information controlling cortical neurogenesis. J Mol Cell Cardiol 5 e15211. PMID: 21170332.

Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1. PMID: 19907129.

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7. PMID: 20085655.

Goffin et al (2010) Dopamine-dependent tuning of striatal inhibitory synaptogenesis. PLoS One 30 2935. PMID: 20181591.

Schapitz et al (2010) Neuroligin 1 is dynamically exchanged at postsynaptic sites. J Neurosci 30 12733. PMID: 20861378.

Byrnes et al (2009) Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. J Clin Invest 57 550. PMID: 18816644.

Roscioni et al (2009) PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res 10 88. PMID: 19788733.

Rao et al (2007) Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. PLoS One 117 4022. PMID: 18060037.

Hosoi et al (2002) Identification of a novel human eicosanoid receptor coupled to G(i/o). J Biol Chem 277 31459. PMID: 12065583.

Do you know of a great paper that uses Forskolin from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Forskolin, supplier, Adenylyl, cyclases, activator, Inositol, cAMP, Signaling, Signalling, adenylate, stem, cells, organoids, Tocris Bioscience, Adenylyl Cyclase Activator products

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