Cat. No. 1097
Alternative Name: Paclitaxel
Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,
Biological ActivityAntitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Park et al (2004) Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 279 51057. PMID: 15452117.
Rao et al (1999) Characterization of the taxol binding site on the microtubule. J.Biol.Chem. 274 37990. PMID: 10608867.
Rowinsky et al (1990) Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 82 1247. PMID: 1973737.
McGuire et al (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 111 273. PMID: 2569287.
Merck Index 12 7117.
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Citations are publications that use Tocris products. Selected citations for Taxol include:
Haghshenas et al (2015) Bioactivity characterization of Lactobacillus strains isolated from dairy products. Microbiologyopen 4 803. PMID: 26219634.
Masocha (2015) Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. PeerJ 3 e1350. PMID: 26528412.
Lin et al (2012) Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer 107 1692. PMID: 23037716.
Natrajan et al (2012) Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res 14 R53. PMID: 22433433.
Lim et al (2009) Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells. Exp Mol Med 41 737. PMID: 19561399.
Pennati et al (2005) Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther 4 1328. PMID: 16170024.
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Keywords: Taxol, supplier, Promotes, assembly, inhibits, inhibitors, disassembly, microtubules, Tau, Tubulin, Mitosis, taxanes, chemotherapeutics, Tocris Bioscience, Microtubule products
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September 20 - 22, 2016